After four successive wins under Danny Cowley, the Blues have recently lost to Burton before drawing at Crewe Alexandra on Tuesday.
As a result, Pompey have dropped to sixth in the League One table and failure to win at Stadium MK could see them moved out of the play-off places.
The Blues’ lack of attacking options are well documented, with Ellis Harrison and Michael Jacobs out for the remainder of the season while Jordy Hiwula’s also absent.
It means Cowley’s unable to rotate any of the players in the front four positions.
However, will Pompey’s boss be tempted to make any further changes from the goalless stalemate at Gresty Road?
Scroll down and click through the pages to see how we think the Blues might line-up...
![A welcome clean sheet for the Scot at Crewe - just his second since the Cowleys arrived.](https://www.shieldsgazette.com/webimg/b25lY21zOjQ4MmJjOTRlLTY2MjEtNDYxNy1hYWZiLTIxODRiYTU2ODBkZDpmZmJiMzIzOC1kZDdlLTQ3YjctYmE3MS03MWY2ZjMyMGVjNzE=.jpg?crop=3:2&width=800)
1. Goalkeeper - Craig MacGillivray
A welcome clean sheet for the Scot at Crewe - just his second since the Cowleys arrived. Photo: PinPeP
![The former Accrington man's performance at Crewe garned praise from Danny Cowley. He's very much first-choice right-back.](https://www.shieldsgazette.com/webimg/b25lY21zOjU1MDRmZjQyLWE1ZjUtNDFlYS1hY2JiLTFlZDJhYTVmMzRlNDo5ZjVlNDZiNy0xOTI5LTQ5NDMtYTkyYy00MmJhNThkMzIzNzA=.jpg?crop=3:2&width=800)
2. Right-back - Callum Johnson
The former Accrington man's performance at Crewe garned praise from Danny Cowley. He's very much first-choice right-back. Photo: Pinpep
![The Gosport lad was lauded as a Championship player in the waiting after Crewe by Danny Cowley.](https://www.shieldsgazette.com/webimg/b25lY21zOmMyNTE0OGQwLTg2NDUtNDQ0ZC1iYzE1LTBlMzQ2MjZhYzZiNjpmOTJiYWY3MS1iNmZiLTQxNTktOWI3Zi04YjE2NGE3YjIxMWM=.jpg?crop=3:2&width=800)
3. Centre-back - Jack Whatmough
The Gosport lad was lauded as a Championship player in the waiting after Crewe by Danny Cowley. Photo: Jason Brown
![Perhaps isn't the most suited to playing out from the back but he gives Pompey plenty of other attributes that are needed when it comes to defending.](https://www.shieldsgazette.com/webimg/b25lY21zOjgwYWY4ZTU2LWUzODktNGExZS05NzEwLTgzNzJhNmQyNTViYTo0NjBmOWJhNy1mNzAyLTRkZTgtOTkxYy1hYTcwNTUzOTVjOTI=.jpg?crop=3:2&width=800)
4. Centre-back - Sean Raggett
Perhaps isn't the most suited to playing out from the back but he gives Pompey plenty of other attributes that are needed when it comes to defending. Photo: Joe Pepler