Pompey's top goalscorer continues to be linked with a move away from Fratton Park in the January transfer window.
But Adams insists the fantastic support he is getting from Blues owner Sacha Gaydamak means he will not be forced into selling any of his top stars.
Defoe spurned a host of chances to bury wobbling West Ham in the goalless draw at Upton Park on Saturday.
Despite his off-day in front of goal, though, Adams has no doubt the front-man will help him 'stay in this job by scoring goals'.
Pompey's boss said: 'Defoe's a threat in front of goal and I'm sure there will be some big clubs trying to get him, but hands off because he's mine.
'Big offers? I can't wait because the owner has been very supportive and although I've not made an issue of it I've told him that everyone stays who I want to stay or I don't do the job.
'I told him that at the very start.
'He was very supportive of Harry (Redknapp) and now he's being very supportive of me.
'He phones me on the way home and says "what do you want, Tony, how can I help you" and I say "keep J Defoe where he is and there's no problem".
He says "fine, anything else?" He's totally behind me.'
Previous reports have suggested Pompey would have to sell or offload star players in January to ease alleged debts.
But ex-Arsenal and England ace Adams told The News last week he has his eye on one or two signings in the next window, while Defoe himself revealed he was not looking for a move away from Fratton Park.
Adams' comments also suggest he is confident of keeping the likes of Lassana Diarra at the club beyond the January transfer window.
The classy Frenchman has been continually linked with a move away as well, with former Blues boss Harry Redknapp believed to be keen to take him to Spurs.
However, Diarra is set to be out of action for Pompey for the next three weeks.
The centre midfielder left Upton Park on crutches on Saturday with a suspected ankle injury.
The Blues' biggest asset limped off in the first half following a crunching tackle from West Ham's Scott Parker.
And Adams will be made to wait to find the extent of the problem, with Diarra forced to link up with France ahead of their international with Uruguay this week.
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The full article contains 456 words and appears in The News newspaper.