Crouch put Pompey ahead in the 25th minute with a marvellous overhead scissors kick after good work from Defoe and a pinpoint cross.
But Stoke were a threat all day from set-pieces - particularly from Rory Delap's long throw-in - and Fuller grabbed an equaliser as he bundled in from close range just two minutes after the interval.
Defoe struck the winner and his sixth of the season in the 51st minute with a low drive, just moments after crashing a long-range effort against the post.
>>> Click here to watch the goals go in at Fratton Park as Pompey take on Stoke.>>> Also see: Burton's Banter - Pompey defeat the anti-football. Click here to read our blog.Never miss a Portsmouth FC story... Get them sent straight to your e-mail inbox.... click here to subscribe.
The full article contains 161 words and appears in The News newspaper.