Brave Joe Way was born with the genetic condition Angelman Syndrome, which left him severely disabled.

The four-year-old spent most of last year in intensive care where he beat off 10 different superbugs in just eight months.

But he developed a second rare condition, called Stevens-Johnson Syndrome, which caused blisters over 80 per cent of his body and internal organs.

He survived an attack of the disorder in July 2006, but the condition returned and Joe died surrounded by family on May 7.

Grandparents Chris and Sid Way, of First Avenue, Farlington, Portsmouth, said: 'We were so very sad to lose him. He really has gone through so much and still continued to charm everyone with his stunning smile, but he had suffered so much.

'As grandparents it has been hard to watch our grandson fighting so bravely.'

Joe, who lived in Newquay with mum Claire and dad Matt Way, a former Crookhorn school pupil, inspired a mammoth fund-raising effort with his constant courage and cheerful smile.

Family and friends raised more than £6,000 for the high dependency unit at the Royal Cornwall Hospital where he spent most of his time.

Portsmouth man John Simmonds completed the Great South Run on Joe's behalf and donated the money to the cause.

Mrs Way, 56, added: 'We are so very proud and in awe of how our son Matt and his wife Claire have loved and cared for Joe.

'They have been with him every step of the way and he could not have wished for better parents.

'We would like to thank all our family and friends in the Portsmouth area who supported fund-raising efforts for Joe – none of it will be forgotten.'

His parents will continue to raise funds in Joe's name for the Precious Lives Appeal.