Hayling United will have to upset the form book if they are to get their Wessex premier division survival bid back on track against hosts Moneyfields at Dover Road (3pm).
The home side are unbeaten in their past 11 league games, winning 10 of them, and will start as firm favourites.
Meanwhile, Hayling are rock bottom and find themselves battling against relegation once again.
Despite the huge task on their hands, though, Humbugs boss Steve Poulton insists his men are capable of causing a derby upset – but admits they need to show a big improvement.
‘From our point of view, we have nothing to lose and are looking for an improved performance,’ said Poulton. ‘It is a game everyone expects us to lose but you never know what might happen in derbies.
‘We have a good record in local games this season, beating Horndean, drawing with Fareham twice and, unluckily, losing by the odd goal in the first game against Moneyfields.’
Jack Salter-Vaile is an injury doubt for Hayling but the visitors are boosted by the return of the influential Sean Thurgood.
Moneys go into the game badly hit by suspensions and injuries.
Steve Hutchings, Luke Middleton and George Davis are all banned, while Danny Boyle and Louis Savage are injured.
‘Hayling are a bit of a bogey side for us,’ said Moneys manager Miles Rutherford.
Moneyfields: Hook, Evans, Wain, Horrell, Rackley, Lee, Gauntlett, Birmingham M, Lacey, Gregory, N’Doye, Asajile, Bailey, Slater.
Hayling United: Patilla, Black, Case, Gadd, Hayward, Kendall, Easton, Thornton, Tigwell, Watts, Baker, Kinchen, Thurgood, Salter-Vaile.
n Struggling Horndean are looking to pull off a surprise against visitors Christchurch at Five Heads Park (3pm).
The Deans put in an improved performance against Alresford last weekend but still lost 2-0, leaving them deep in a relegation battle.
‘We played a lot better and created a lot of chances,’ said Horndean boss Dave Carter.
‘We hit the crossbar three times, the post once and had another effort cleared off the line.
‘Our luck has to change soon and we are looking for three points against our organised visitors.’
Striker Torr Spicer is unavailable but, otherwise, Carter has a full-strength squad to choose from.
Horndean: Howard, Smith, Shepherd, Chapman, Fennemore, Hayes, Spurway, Milroy, Martin, Bell, Fenelon, Paxton, McKie, Perkins, Luff, Austin, Blackmore.
n Mid-table Fareham Town journey down to the Waterside to take on Fawley.
The Reds have been boosted by the return of goalscorer Graham Lindsey who comes straight into the squad from Winchester City.
‘You know what you are going to get from Graham,’ said manager Matt Parr.
‘Goals, goals and more goals.’
Fareham Town: Douglas, Smith, Jones, Doswell, Cuthbert, Boud, Stevens, Burt, Pittman, Cotton, Tattersall, Tambling, Lindsey, Lewis, Vickers, Martin, Windsor.