Pompey host Plymouth on Saturday in front of a packed house at Fratton Park, with both teams chasing promotion from League Two.
Anything less than a win for either, though, could see hopes of a top-three spot suffer a major blow.
So before the eagerly-anticipated game, we’ve taken a trip down memory lane to look at some of the players that have played for both clubs.
Let us know if we’ve missed anyone in the comments...
Steve Davey - Born Plymouth 5/9/1948
Appearances for Pompey: 93 Goals: eight
Appearances for Plymouth: 224 Goals: 47
Steve Davey started his career as a striker at his hometown club. He spent nine seasons at Home Park before moving to Hereford United.
In 1978, Jimmy Dickinson spent £10,000 on Davey, with Pompey rooted in the fourth division. Despite being signed as a striker, he spent the majority of his career on the south coast playing in the middle of the park.
With Pompey needing a win to gain promotion in 1980, Davey scored his most important goal for the club, opening the scoring in a 2-0 victory against Northampton.
Nicky Jennings - Born Wellington 18/1/1946
Appearances for Pompey: 206 Goals: 45
Appearances for Plymouth: 98 Goals: 11
Nicky Jennings scored four goals in his first season for Plymouth, as they avoided relegation from division two by just 0.004 of a goal.
His performances for the Devon club didn’t go unnoticed and he was signed by Pompey in 1967, scoring on his debut.
He became a fans’ favourite during his time on the south coast and won the player of the year award in 1970.
Jake Jervis - Born: Wolverhampton 17/9/1991
Appearances for Pompey: 18 Goals: five
Appearances for Plymouth: 25 Goals: eight
Jake Jervis first joined Pompey on a month’s loan in 2012, when they were in League One. After a spell in Turkey with Elazigspor, he rejoined the Blues for the second half of the 2013-14 season, scoring four times.
In June 2015, he linked up with the Pilgrims and is their top scorer this campaign with nine goals.
Paul Mariner - Born Bolton 22/5/1953
Appearances for Pompey: 55 Goals: nine
Appearances for Plymouth: 134 Goals: 56
Paul Mariner was part of the Plymouth team that was promoted to the Second Division in 1975, scoring 20 goals.
Following time at Ipswich and Arsenal, as well as winning 35 England caps, he joined Pompey on a free transfer before the 1986-87 season.
He made 33 appearances that season, scoring five goals, as Pompey were promoted to division one for the first time in 28 years.
David Norris - Born: Stamford 22/2/1981
Appearances for Pompey: 40 Goals: eight
Appearances for Plymouth: 226 Goals: 27
David Norris joined Plymouth originally on loan in 2002 and joined permanently in December that year, going on to make 226 league appearances.
Following a spell at Ipswich he joined Pompey on a free transfer in the summer of 2011 and scored on his debut for the club in a 2-2 draw with Middlesbrough.
Despite only spending one season at Fratton Park, Norris will forever be a cult hero after scoring a last minute equaliser against Southampton at St Mary’s Stadium in 2012.
Norman Piper - Born: North Tawton 8/1/1948
Appearances for Pompey: 313 Goals 51
Appearances for Plymouth: 215 Goals: 35
Norman Piper made his league debut for Plymouth aged 17 in 1965, and at the age of 20, he was named as captain.
In 1970, having made appearances for England under-23s, Ron Tindall paid Argyle £40,000 for Piper, which equalled the club record set in 1968. He scored on his debut in a 1-1 draw against Norwich City.
The 1975-76 season ended with Pompey being relegated to the third division, but Piper finished the campaign as top scorer with 11 goals.
Richie Reynolds - Born: Looe 15/2/1948
Appearances for Pompey: 140 Goals: 24
Appearances for Plymouth: 131 Goals: 24
Richie Reynolds joined Plymouth at the same time as Nicky Jennings and Norman Piper and became the youngest player in Pilgrims history when he made his debut during the 1964-65 season.
Signed on a free transfer by Ron Tindall in 1971, he scored 10 goals in his first season and was rewarded with the player-of-the-year award at the end of the campaign.
Towards the end of his Fratton Park career, he was deployed in midfield, before leaving on a free transfer following relegation in 1976.
Alan Rogers - Born: Plymouth 6/7/1954
Appearances for Pompey: 161 Goals: 15
Appearances for Plymouth: 117 Goals 5
Alan Rogers made 117 appearances for Plymouth over a six-year period, helping them to the semi-finals of the League Cup in 1974 and then promotion to division two the season after.
He was signed for £25,000 in 1979 and scored on his home debut against Swindon in the League Cup. Rogers scored nine goals that season, more then he managed in six years at Home Park.
While at Fratton Park, Rogers helped the Blues to two promotions in three seasons, before joining Southend for £20,000 in 1984.
Mike Trebilcock - Born Gunnislake 29/11/1944
Appearances for Pompey: 109 Goals: 33
Appearances for Plymouth: 71 Goals: 27
Mike Trebilcock joined Plymouth in 1962 and after three years in Devon, he made the switch to first division Everton for £23,000.
After three seasons on Merseyside, in which he scored two goals in the 1966 FA Cup final, he joined Pompey for a club record fee of £40,000 in 1968.
While on the south coast, Trebilcock frustrated the fans with his inconsistent displays, but he will always be remembered for his equalising goal in front of 40,000 against Arsenal in the FA Cup, which created the largest roar heard at Fratton Park in a generation.