The aircraft was hand painted to include the names of thousands of people who helped fight the coronavirus outbreak.
It also had the words ‘Thank U NHS’ emblazoned under its wings.
Crowds on Portsdown Hill and at QA Hospital in Cosham were wowed as the Spitfire performed a special flyby on Saturday afternoon.
Many eager photographers managed to capture spectacular photos of the plane in the skies above our city.
Here are some of the best pictures that were sent in by The News readers.
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1. NHS Spitfire
These spectacular pictures of the NHS Spitfire flying over Portsmouth were taken by Adam Jenkins Photo: Adam Jenkins
2. NHS Spitfire
These spectacular pictures of the NHS Spitfire flying over Portsmouth were taken by Adam Jenkins Photo: Adam Jenkins
3. NHS Spitfire
These spectacular pictures of the NHS Spitfire flying over Portsmouth were taken by Adam Jenkins Photo: Adam Jenkins
4. NHS Spitfire
These spectacular pictures of the NHS Spitfire flying over Portsmouth were taken by Adam Jenkins Photo: Adam Jenkins