Both casualties and two others were thrown clear when the car hit a lamp-post at Bradford Junction, Southsea, and were taken to the Royal Portsmouth Hospital.
The driver and one of the passengers were thrown out of the vehicle.
Firemen began prising the car open with hydraulic jacks to release the remaining two passengers, but found it impossible to do while the pair were conscious.
Reinforcement firemen and an anaesthetist were called.
A police radio link between the police surgeon, the Accident Unit at the hospital, and the anaesthetist was used.