The Royal Navy aircraft carrier left the naval base on Monday after days of delays and will continue the latest round of training with F-35 fighter jets.
Queen Elizabeth had been due to sail last week but that was postponed several times.
Hundreds of people socially distanced as they lined the shore in Old Portsmouth to give the carrier a proper send off on Monday afternoon.
Check through our gallery below to see if you were in our pictures from the crowd.
1. HMS Queen Elizabeth
HMS Queen Elizabeth left Portsmouth on Monday afternoon and crowds came to give her a proper send-off. Picture: Finnbarr Webster/Getty Images Photo: Finnbarr Webster
2. HMS Queen Elizabeth
Crowds watch as HMS Queen Elizabeth departs from Portsmouth Naval base. Picture: Finnbarr Webster/Getty Images Photo: Finnbarr Webster
3. HMS Queen Elizabeth
Crowds gather to give HMS Queen Elizabeth a proper send off. Picture: Finnbarr Webster/Getty Images Photo: Finnbarr Webster
4. HMS Queen Elizabeth
Crowds gather in Old Portsmouth to give HMS Queen Elizabeth a proper send-off. Picture: Finnbarr Webster/Getty Images Photo: Finnbarr Webster