Around 20,000 runners are expected to visit Portsmouth to take part in the 10 mile run.
The Great South Run was cancelled last year due to the Covid-19 pandemic.
This year’s 10 mile run will be held on Sunday, with the 5k, Junior and Mini runs taking place on Saturday.
Runners and spectators will now be in full preparation for the weekend ahead and here is what weather you can expect in Portsmouth, according to the Met Office.
5k, Junior and Mini events
On Saturday, runners and spectators can expect cloudy conditions throughout the day.
There will be highs of 16C and lows of 14C.
Great South Run
On Sunday, runners and spectators can also expect cloudy weather, according to the Met Office.
There will be highs of 15C and lows of 12C between 10am and 1pm.