Hampshire maintained their advantage over leaders Middlesex on day two of the County Championship contest.
The Ageas Bowl hosts capitalised when the heavy morning rain relented to allow play to start at 2.15pm.
A partnership of 91 between Will Smith (93) and Gareth Berg (50) carried Hampshire past 400.
Neil Dexter claimed four of the five Hampshire wickets to fall in the day with his medium pace to achieve figures of five for 64.
The hosts were eventually all out for 413.
In reply, Hampshire began brightly with the ball and debutant Brad Wheal produced a quick delivery which nipped back to bowl Sam Robson.
Fidel Edwards then struck with his first delivery to pin Nick Gubbins lbw.
The away side appeared to have weathered the early pressure as they battled on.
But with the partnership worth 69 runs and Nick Compton 32 not out, Joe Burns edged a Sean Ervine delivery to Adam Wheater to underline the hosts’ ascendency.