Horndean are aiming to ensure they finish as Christmas number one in the Wessex League premier division.
The Deans will be looking to beat Cowes Sports at Five Heads Park (3pm).
Confidence is high in the camp but we still need to be cautiousSimon Chamberlain
They currently hold a three-point lead ahead of Salisbury and a seventh successive win would guarantee them top spot at Christmas.
Assistant manager Simon Chamberlain believes it would be a first for the club.
He said: ‘No-one at the club can remember us ever doing it before.
‘Confidence is high in the camp but we still need to be cautious of Cowes.
‘We beat them 5-3 at their place so we know they can score goals.’
Third-placed AFC Portchester can maintain pressure on the leading pair by exacting revenge on Whitchurch United at Wicor Rec (3pm).
The Royals have lost only once in the league and that was at Whitchurch earlier in the season.
Graham Rix’s side are confident they can chalk up a seventh-successive win.
The Portchester boss said: ‘We should be okay if we keep approaching the games in the right way.
‘At the moment we are on a good little run and are playing well.
‘Defensively we look solid and are threatening going forward.’
Moneyfields host Hamworthy after learning their bid to play their FA Vase replay at Brimscombe & Thrupp was turned down.
The Copnor club will have to make the long midweek trip to Gloucestershire next Tuesday after drawing the first tie 0-0 at home.
‘It isn’t ideal but it could be a blessing in disguise,’ said manager Dave Carter.
‘The delay means we will have three more players available and we can go there stronger.
‘In the meantime it would be nice to pick up three points.’
Carter has his five cup-tied Vase players available for the league and also hinted at the arrival of a couple more new faces before the weekend.
‘We had our transfer embargo from taking players from Horndean lifted in the week,’ said Carter.
‘I have already made two seven-day approaches for players.’
Fareham Town face a testing trip to Sholing Sports with manager Steve Stone trying to get his players fit.
‘We have not been able to train or play much in the last six weeks because of the weather,’ said Stone.
‘It is a case of going there and doing some damage limitation.’