The central midfielder is expected to sit out tomorrow night’s trip to Crawley with a hamstring issue.
Pompey’s medical team believe Linganzi’s injury is fatigue related and, as a result, is likely to be taken out of the side.
The former Blackburn player has established himself in Paul Cook’s side following a sizeable period served as a fringe player.
However, seven games in 29 days have taken their toll, culminating in his substitution against Crewe after 50 minutes.
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His absence tomorrow evening would put Danny Rose and Stanley Aborah in the reckoning to serve alongside Michael Doyle.
Regardless of who gets the nod for a match which could see the Blues break into the top three, Cook believes the summer arrival needs to rest.
Pompey’s boss said: ‘We think Amine is just suffering from a bit of fatigue, he has played a lot of games.
‘It’s his hamstring now, this is moving around his body and is down to tiredness and the amount of games.
‘Amine has played a lot of matches in a quick space of time for us, so we believe it is a little bit of fatigue, so watch this space.
‘At the minute, I wouldn’t say he is out, but I also wouldn’t say he is playing.
‘He’s a big doubt, we think his injuries are down to general fatigue.’
Linganzi was also withdrawn in the midweek draw to Morecambe, albeit on that occasion with a groin concern.
He has just recorded seven successive league starts – his longest spell in Pompey’s first-team.
Overall, the free-transfer recruit has made 21 appearances, scoring once, during a maiden season on the south coast.