As the race for an automatic promotion place hots up, Pompey will be hoping for other sides to do them a favour as they look to claw back the eight-point gap to third-placed Plymouth.
The good news for the Blues, who have a game in hand over the Pilgrims, is the Green Army are in for a tough test as they travel to rivals Exeter for the Devon derby.
The Grecians have been in fine form recently, with four wins and three draws from their past seven games – and in ex-Pompey loan striker Jayden Stockley they have a forward in fine form.
Stockley, who made the switch to St James Park at the start of the year, has scored eight goals in 15 games to top Paul Tisdale’s side’s scoring charts.
And a decisive strike on Saturday will be cheered by his former club on the south coast and the rest of the chasing pack.
With Northampton well clear at the top of the table and second-placed Oxford United in Johnstone’s Paint Trophy final duty at Wembley, attention turns to fourth-placed Accrington.
Stanley are the most in-form side in the division having won their past three matches and will be confident of toppling a mid-table Cambridge side who have registered just one victory in their last five outings.
Fifth-placed Bristol Rovers saw their stunning six-game winning streak come to an end last time out at Carlisle, and Darrell Clarke’s men will be looking to bounce back to winning ways when they entertain Crawley.
Wycombe sit one place and two points below Pompey in the seventh and final play-off spot.
A push for an automatic-promotion place seems unlikely for Gareth Ainsworth’s side who will instead be looking to ensure their place in the top seven.
They host AFC Wimbledon and will hope to extend a five-game unbeaten run in the division with a positive result at Adams Park.
Leyton Orient boast the division’s top goalscorer in Jay Simpson but are two points behind the Chairboys as the duo appear set for a fight for the final play-off spot.
The eighth-placed O’s travel to lowly York in a game they will be looking to win.