Tom Naylor is set to return to the Pompey fold for Saturday’s visit of Southend to Fratton Park.
The midfielder has recovered from the groin problem that forced him to miss Sunday’s FA Cup victory against Rochdale.
The former Burton man, with 21 Blues appearances this season, picked up in the injury last week in training.
But boss Kenny Jackett confirmed he – along with Joe Mason – will be fit to play against the Shrimpers.
Mason made his return from a groin injury against Arsenal under-21s in the Checkatrade Trophy on Tuesday night.
Jackett said: ‘Tom Naylor’s fine.
‘He’ll be fit for the weekend, which is good news for us.
‘Joe Mason came on as a substitute on Tuesday night and he’s fit as well, so everybody’s present and correct barring David Wheeler and Dion Donohue.’
On-loan QPR winger Wheeler is currently sidelined with a back/hamstring injury and is expected to be out for a further two to three weeks.
Donohue is continuing his rehabilitation from the hamstring problem he picked up in October’s 2-2 draw with Burton – but is not too far away from a Pompey return.
Jackett added: ‘Wheeler’s probably two or three weeks away.
‘Dion Donohue has started training which is really good news for us.
‘Hopefully, within a week to 10 days he’ll be pushing and ready to get back in.’