Rommy Boco and Michael Poke have left Pompey by mutual consent.
Versatile Boco, who joined the club as a free agent in September, made his debut at Newport in October.
The 30-year-old Benin international played a total five games for the Blues.
Goalkeeper Poke joined the Fratton Park club in the summer of 2014 as competition for Paul Jones.
He leaves without making a single first-team appearance after two loan spells at National League Eastleigh.