Nigel Atangana is expected to miss the trip to Burton.
The midfielder suffered a tight hamstring against Yeovil in the Johnstone’s Paint Trophy and was forced off after 43 minutes.
It was the Frenchman’s first start in three games as Andy Awford shuffled his team for the 3-1 victory.
Now according to Awford, he is set to miss Sunday’s visit to the Pirelli Stadium.
Pompey’s boss said: ‘It is a tight hamstring. It hasn’t gone but it is tight.
‘We had to get him off – there was no point him carrying on. He was only going to make it worse.
‘We will assess that but I doubt he will make Sunday.
‘However, we won’t know for about another 24 hours.’
Ben Chorley (dead leg) and Joe Devera (neck) missed the Huish Park fixture but are anticipated to make a return this weekend.
Jack Whatmough is also now back in training following his left ankle injury and will be in the frame.
Meanwhile, Patrick Agyemang made his first appearance of the season at Yeovil as a substitute having recovered from a pre-season hamstring tear.
There was also a squad return for Michael Poke and both are in the frame to make the match-day 18 at Burton.
However, Nick Awford’s availability is being monitored after coming off against the Glovers.
The Blues are concerned over an ongoing shoulder complaint.
Awford added: ‘I thought Nick was hurt.
‘He’s got a history with his shoulder. As a schoolboy he dislocated it twice, he first did it on a skiing holiday at the age of 14.
‘When he went down on Tuesday I thought he had done it again but he managed to stay on and was excellent.’