Gareth Evans has made a full recovery from the ankle injury he suffered against Leyton Orient last time out at Fratton Park.
Pompey’s right-back was forced off at half-time in the 2-1 win over the O’s, having been injured in a tackle with Sammy Moore.
Evans, though, has declared himself fully fit to return to action for Saturday’s Exeter visit.
One man who won’t be a part of Paul Cook’s plans is long-term injury absentee Curtis Main.
The striker, signed from Doncaster in the summer, had initially been ruled out with an abodminal strain but now has a knee injury.
For Exeter, in-demand Ollie Watkins is the player in form for the Grecians.
The forward was the subject of a £350,000 bid from Mansfield earlier this week, interest which was rejected.
He will operate behind former Pompey target Reuben Reid as the in-form Grecians seek to make it five successive victories.
Paul Tisdale will, however, once again be without one-time Blues loanee Lee Holmes (ankle injury).
Joining the winger on the sidelines is Tom McCready, who has not played since August following a groin problem.