Pompey could find themselves back in the play-off places if results go their way tomorrow
The Blues currently occupy ninth place on 49 points - but could jump into sixth - leapfrogging Charlton Athletic, Plymouth Argyle and Bradford City - if they defeat Gary Bowyer's side.
Pompey host the 17th-places Seasiders at Fratton Park and it provides Kenny Jackett's troops with a great chance of delivering a first home victory this year.
Meanwhile, sixth-placed Charlton (51) have a tough test as they welcome high-flying Shrewsbury Town (65) to the Valley.
The Blues would realistically need the Addicks to lose to Paul Hurst's side to move into the play-offs.
If Pompey beat the Tangerines and Charlton draw, it would leave both teams level on points - but Karl Robinson's outfit Charlton have a superior goal difference.
Meanwhile, the league's seventh and eighth-placed teams are to do battle as Plymouth (50) and Bradford (50) meet at Home Park.
Nevertheless, the Blues could find themselves as low as 11th if they're defeated by the Tangerines.
Peterborough (46) host AFC Wimbledon, who are in 18th place, whereas Gillingham (46) visit basement-side Bury.
However, the Posh - who sit 10th - have drawn their past three league games and have failed to win in their past five.
Gillingham are unbeaten in 12 of their past 13 league games, only losing at Paul Cook's Wigan.
And 12th-placed Bristol Rovers (45) host fifth-placed Scunthorpe (45).