The Blues achieved unlikely progression from Southern Group B as George Hirst’s injury-time strike forced a four goal swing that allowed the club to leapfrog AFC Wimbledon and Crystal Palace under-21s into second position.
And by doing so, they join a number of League One and development teams in the bookies reckoning to win the competition.
Rivals such as Sunderland, Sheffield Wednesday, Ipswich and Bolton also qualified for the round-of-32, albeit in more comfortable fashion than Danny Cowley’s side.
As a result, we’ve compiled a list on the favourites to find success at Wembley thanks to SkyBet’s odds.
Click through the list to see where Pompey rank.
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1. West Ham U21 - 33/1
Southern Group A position: 1st Wins: 2 Draws: 0 Losses: 1 (Photo by David Rogers/Getty Images) Photo: David Rogers
2. Tranmere Rovers - 33/1
Northern Group B position: 1st Wins: 3 Draws: 0 Losses: 0 (Photo by Pete Norton/Getty Images) Photo: Pete Norton
3. Swindon Town - 33/1
Southern Group F position: 1st Wins: 3 Draws: 0 Losses: 0 (Photo by Pete Norton/Getty Images) Photo: Pete Norton
4. Sutton United - 33/1
Southern Group B position: 1st Wins: 3 Draws: 0 Losses: 0 Picture: Photo: Jason Brown