After impressive wins over Gillingham, Sunderland and Northampton, confidence is riding high in the Blues camp going into the game.
But the same can be said for the Addicks, having triumphed in their past four league games.
It proves to be an intriguing clash and Kenny Jackett will once again have to get his team and tactics spot on to pick up a success.
But will the Pompey boss make any changes to his starting XI? And will he shuffle his bench? We take a look at the likely match-day 18...
1. Goalkeeper - Craig MacGillivray
Pulled off a fantastic save against Northampton and aiming for a fifth league clean sheet. Photo: Joe Pepler
2. Right-back - Callum Johnson
Made a solid start at Pompey and put in a lovely cross for Ronan Curtis' goal against Northampton. Photo: Joe Pepler
3. Centre-back - Jack Whatmough
Continuing to be a dominant figure in the heart of the rearguard and proving he's capable of playing two games per week despite previous injuries. Photo: Joe Pepler
4. Centre-back - Sean Raggett
There was a nervy moment against Northampton when he lost the ball and had a coming together with a Cobblers man. But it'd be very harsh to drop a player who's been part of a defence that's conceded once in three games. Photo: Daniel Chesterton