The Blues have eighth fixtures throughout the month, facing League One promotion rivals including Peterborough, Ipswich, Fleetwood and Hull.
But Kenny Jackett’s full focus will be returning to the south coast with three points from Bloomfield Road.
The Pompey boss made five changes for Saturday’s 6-1 thrashing of King’s Lynn Town in the FA Cup.
He gave players such as Rasmus Nicolaisen, Cam Pring and Ben Close run-outs to rest some key players.
But with the Blues’ fringe men impressive in the routing, they’ll be hoping they’ve staked a claim to start against the Seasiders (7pm kick-off).
Jackett has to decide what, in his mind, is his best starting line-up to defeat Neil Critchley’s men.
We've predicted who’s likely to feature from the outset and be on the bench against Blackpool below...
1. Goalkeer - Craig MacGillivray
Was given a rest against King's Lynn in the Cup on Saturday but has re-established himself as No1 stopper and is set to come back into the team. Photo: PinPeP
2. Right-back - Callum Johnson
After being dropped against Crewe, the former Accrington man has really come to the fore since coming on at half-time against Alexandra. Will have to be on his toes to nullify some pacy Tangerine attackers. Photo: Daniel Chesterton
3. Centre-back -Jack Whatmough
Was wisely rested on Saturday given his previous injury problems. One of the first names on the team sheet. Photo: Joe Pepler
4. Centre-back - Sean Raggett
Took his tally up to three goals on Saturday and has established himself as a key player once again. Photo: Joe Pepler