The Blues are aiming to bounce back to winning ways after being held to a 2-2 draw at Plymouth Argyle on Monday evening.
It’s been Pompey’s home form that’s been hampering their League One promotion push so far, having lost to Charlton in their last game at PO4.
And Crewe travel to the south coast in good form, having defeated leaders Peterborough and last season’s play-off finalists Oxford United in their past two games.
Kenny Jackett has to weigh up his starting line-up that will best equipped to beat Alexandra.
He was Lee Brown back from a hamstring injury, while Ronan Curtis returns after being on duty with the Republic of Ireland.
So who could be given the nod by Jackett to feature from the outset, who’ll make the bench and who might be left out of the match-day squad.
Scroll down and click through the pages to see how we predict Pompey’s match-day squad to look...
1. Goalkeeper - Craig MacGillivray
The keeper was at fault for Plymouth's second goal on Monday, but received Kenny Jackett's backing after the game. It was his first real mistake of the season. Photo: Daniel Chesterton
2. Right-back - Callum Johnson
Got caught out a couple of times in the first half at Plymouth but firmly remains first choice. Photo: Joe Pepler
3. Centre-back -Jack Whatmough
Was imperious after coming on at Plymouth for Rasmus Nicolaisen. Fully over his hamstring injury and should make his return to the starting XI. Photo: Joe Pepler
4. jpns 311020 pompey charlton.JPG
Couldn't have done too much else when he scored an own goal at Plymouth. Remains well favoured by Kenny Jackett. Photo: Joe Pepler