After four successive wins under Danny Cowley, the Blues have recently lost to Burton before drawing at Crewe Alexandra on Tuesday.
As a result, Pompey have dropped to sixth in the League One table and failure to win at Stadium MK could see them moved out of the play-off places.
The Blues’ lack of attacking options are well documented, with Ellis Harrison and Michael Jacobs out for the remainder of the season while Jordy Hiwula’s also absent.
It means Cowley’s unable to rotate any of the players in the front four positions.
However, will Pompey’s boss be tempted to make any further changes from the goalless stalemate at Gresty Road?
Scroll down and click through the pages to see how we think the Blues might line-up...
5. Left-back - Charlie Daniels
Showed some good glimpses at Crewe and impressed his boss. The ex-Bournemouth man should feel less rusty and open to further improvement.
Photo: Jason Brown
6. Centre-midfield - Tom Naylor
Admitted he has held talks about a new deal as the captain remains a key player since the Cowleys' arrival.
Photo: Joe Pepler
7. Centre-midfield - Ben Close
Enjoying his revival under the Cowleys, although there is strong competition from Andy Cannon, Harvey White and George Byers for his starting spot.
Photo: Joe Pepler
8. Right-wing - Marcus Harness
Perhaps dipped slightly in the past two games after thriving following the Cowleys' arrival. However, the boss have been informing Harness what's required to get back to his very best.
Photo: Daniel Chesterton