However, the Blues face an experienced Wycombe side determined to be in the play-off picture at the end of the season as well.
Here’s everything you need to know ahead of kick-off (3pm).
5. Danny Cowley - what's he said?
'Wycombe are a team that was put together in the Championship and they have real power, pace and athleticism. They will ask you a lot of questions physically and seem to be mixing their game up a bit now, which can cause more problems. We have a lot of respect for Wycombe and they are where they are in the league for a reason, but it’s a great opportunity for us to respond.' Photo: Daniel Chesterton
6. Gareth Ainsworth - what's he said?
‘Portsmouth will be coming at us. I have no doubt about the Cowley’s and what they’ll be planning against us, especially at home. They have great support, we will travel in good numbers and I can’t wait for the game. They are always tough games.' Photo: Marc Atkins
7. Match odds
Pompey - 21/20; Wycombe - 9/4; Draw - 12/5 (Bet 365) Photo: Catherine Ivill
8. Match referee
Ben Speedie: This is the first time Speedie has taken charge of a Pompey game this season. He averages three yellow cards per game. Photo: Nathan Stirk