Ellis Harrison is challenging for a Pompey starting spot against Gillingham.
Harrison replaced John Marquis at half-time at the Keepmoat Stadium and headed home in stoppage-time to deliver Kenny Jackett's men a 2-1 success.
With the summer signing from Ipswich scoring his fifth of the season, it could earn him a place in Pompey's XI.
Marquis is fit to feature against the Gills after bruising a toe at Donny.
The winger picked up a hamstring injury and was not included to face Doncaster.
Craig MacGillivray misses the clash as he’s on international duty with Scotland, while Ross McCrorie is away with the under-21s.
Meanwhile, Steve Evans is expected to make a number of changes for Gillingham's trip to Fratton Park.
The Gills had a much different look in the 4-0 Leasing.com Trophy defeat at Ipswich on Tuesday.
But Evans is likely to restore the majority team that were 3-1 victors over Southend in League One last weekend.