It comes after the Boxing Day fixture between the two was postponed due to a surging number of coronavirus cases in the Blues ranks.
At the time, Pompey were on a nine-match unbeaten run in the league, while the U’s were still smarting from a home loss at the hands of Wigan.
Now Danny Cowley’s under-performing side face a Karl Robinson outfit in a rich vein of form.
The U’s will be buoyed after putting seven past Gillingham last weekend, before recording a 1-1 draw away at high-flying Wigan in midweek.
Meanwhile, fresh from a Fratton Park defeat to Charlton, the Blues boss will have a number of key selection decisions to make if he is to get Pompey’s season back on track up the A34.
Here’s how we think Pompey will line up for the trip to Oxford.
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Now Danny Cowley’s under-performing side face a Karl Robinson outfit in a rich vein of form.
5. RWB: Mahlon Romeo
Although his stellar performances have dropped off in recent weeks, Romeo is still the club's best and most comfortable right-wing-back. Photo: The News
6. CM: Louis Thompson
Thompson will benefit from Shaun Williams' unfortunate injury by regaining a place in the starting XI. However, questions remain over his long-term fitness. Photo: The News
7. CM: Joe Morrell
Morrell is one of the first names on Danny Cowley's team sheet, due his unrivalled quality and individual displays in recent weeks. Pompey would be lost without him. Photo: The News
8. LWB: Denver Hume
Showed promise on debut against Charlton with impressive attacking and defensive displays. Will be a mainstay throughout the rest of the season. Photo: The News