The QPR loanee will tonight be handed only his third Pompey start following an August arrival.
The impressive form of Lowe on the right of the attacking three has proven a frustrating barrier toÂ Wheeler's first-team aspirations.
Lowe has seven goals this season, establishing him as the Blues' leading scorer, and remains a chief creative presence for the League One table-toppers.
Wheeler netted his second goal of the campaign after replacing the former Hampton & Richmond player in the weekend FA Cup victory over Maidenhead.
And the 28-year-old tonight has the opportunity to again catch the eye when he starts against Spurs under-21s in the Checkatrade Trophy.
He said: '˜JamsÂ has been a big part in the success this season and deserves his place.
'˜That's just the way it has fallen and I will obviously just be working hard to play when I can.
'˜I need some good minutes to make sure I am fully match fit, so when I am needed in the league and the cup games I'm fully ready to take it.
'˜I hadn't seen too much of Jams before I came to the club, andÂ as much as his ability on the pitch, there isÂ how humble he is off the pitch, and it's a credit to him.
'˜Of course it has been frustrating, any footballer wants to start week in, week out and be involved in the team and to experience Saturday afternoons.
'˜I am definitely frustrated, but just try to approach it in the right way.
'˜You don't want to wish ill on the team because you are part of the squad and want the best for the lads you are with day-to-day '“Â and at aÂ club you are committed to.
'˜You have to keep yourself fit, positive and just take the chance as and when it comes, whether through hard work and you are training well or whether there's a fortuitous circumstance.'
Wheeler, who has nine Blues appearances, missed three games with an ankle injury last month.
That set-back has ensured his Fratton Park time has still to take off in pursuit of regular football.
He added: '˜I wouldn'tÂ say QPR are happy with me not playing.
'˜I wouldn't imagine they would be happy about it, but it's one of those things.
'˜When I was there at the start of the season, opportunities for me were limited asÂ they've got a relatively big squad '“ so it's more about what's best for me.'