Gosport & Fareham are hoping to cause an upset as second-placed Chobham visit Gosport Park in London one south.
The hosts are in a confident mood after picking up their first away win in the league for 14 months at Cobham.
Chobham, however, will be equally confident after beating league leaders Wimbledon in their last game.
‘We know we will have to be at our very best if we are to upset Chobham,’ said head coach Neil McRoberts.
‘Since Christmas, though, we have consistently put in good performances.
‘In our last home game we had a cracking win over Guildford, who are another one of the top sides.’
Skipper Tim Snowden moves back into the hooker role with Ed Pascoe expected to return from navy action at wing forward.
Outside-half Sam Foster has recovered from the rib injury he picked up against Guildford, which means Rory Penfold can return to his usual wing position.
Meanwhile, Fareham Heathens are bidding to upset third-placed Millbrook in Hampshire one.
Having pushed United Services all the way last week, coach Bernie Rhodes is looking for more of the same.
‘With a little bit better decision making in the final third we would have got something,’ he said.
Unbeaten Hampshire two leaders Locks Heath Pumas have no intention of being tamed by Southampton at Brookfield School.
The fourth-placed visitors possess a big pack of forwards and an outside half who can control games.
Pumas coach Jim Pearce, however, has been preparing his team to counter-act them.
‘We now have five weeks without a break which should help us raise our intensity levels,’ he said.
‘Although we have a seven-point lead at the top, we cannot afford to be complacent.’
Experienced prop forward Harry Cripps is expected to play for the first time since October and Pumas also hope to field back-row pair Gavin Hart and Jon Barfoot.
Joel Stocker is away, so Cary Aston is drafted in.
The hosts are also without leading try-scorer Stuart Forbes because of injury.