Last December saw the first-ever Gland Rock one-day festival held in the city, in aid of the Feel Yourself campaign.
This weekend it is back in a new venue, bigger and better than before.
Feel Yourself was started by Maddie Wallace in May 2013 as the result of her own battle with breast cancer.
Maddie, from Southsea, set up the charity to promote cancer awareness for both women and men.
And her friends from the local music community decided they wanted to do something to help – as a result, Gland Rock was born.
The first successful day was held on December 7 last year at the Southsea Social Club, starring the likes of Esben and the Witch, Wild Smiles, Traams and the Hundredth Anniversary.
This time out, the organisers have managed to secure the legendary psychedelic space-rockers The Telescopes, alongside an impressive and eclectic mix of local and national acts.
The likes of God Damn, AK/DK and Playlounge have fast become favourites of gig and festival goers across the country. Elsewhere, they have the bewilderingly exciting Omi Palone and Human Hair, two of the capital’s finest new bands.
On the home front, Southsea is well represented by the bombastic Curxes, You’re Smiling Now But We’ll All Turn Into Demons, Rickyfitts, Deluxe Flamingos, All About The Song contest winner Eloise Keating and Wildest Dreams.
The day is being co-hosted by Champagne Justice, Creation for Causes and Strong Island Recordings.
Alasdair of Champagne Justice says: ‘We’ve been putting on regular gigs around Portsmouth now for about two years, promoting local acts, and putting on things that are perhaps a bit more left-field and alternative. The Portsmouth scene is really exciting right now – there’s a lot going on.
‘I’m a friend of Maddie’s and I’m also a trustee of Feel Yourself.
‘Maddie is one of the most amazing women I have ever met. I know people say Mr T beat up cancer, but I think it’s safe to say that she did.
‘Last year went really well, so we wanted to do it again, but we thought it would be nicer to do it earlier in the year and expand it in to the Wedgewood Rooms.
‘We wanted to bring in some exciting bands from outside, but we also wanted it be a day where we could promote local bands too.’
The charity will have a stall a the event alongside stalls selling records, clothing and art. And the 101 Reykjavík cafe will be providing food.