The smash took place on the northbound route of Northern Parade, in Hilsea, shortly after 3.30pm.
Six police cars, alongside an ambulance, attended the scene, as officers used a van to create a road block.
The vehicle, a grey Toyota Corolla, was seriously damaged, with its bumper hanging off and its entire front left wing and passenger door wrecked.
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Witnesses living nearby said it was lucky nobody else was seriously injured and added they were baffled at how the collision took place, as the road was ‘very quiet’.
One passer-by, who wished to remain anonymous, said: ‘I came outside and saw all the police on the road.
‘They must have crashed into the side of the lorry – it’s cut the car apart like a tin opener.
‘It’s a strange accident because there’s nobody else on the roads at the moment.’
Andy Allright, 60, lives in Northern Parade opposite the crash site. He said: ‘I was up in my loft and heard this mighty great bang.
‘But nobody saw anything or how it happened.
‘If this had happened on a normal day, with people walking about, I dread to think what could have happened. It was lucky it was quiet.’
The driver of the ruined motor was treated by paramedics at the scene and taken to Queen Alexandra Hospital, in Cosham.
A spokesman for Hampshire police confirmed the incident and added: ‘One person has reported chest injuries.’
It’s understood that nobody was in the large van when the crash took place. Nor were any pedestrians injured.
The vehicle was recovered at about 5pm and the road re-opened shortly after.