The RSPCA is investigating after the pups - who are just days old and don't yet have their eyes open - were discovered in a plastic box wrapped in a blanket in Titchfield Lane in Wickham by a member of the public.
The tiny puppies were rushed to a vet where they are now receiving immediate treatment as they are completely reliant on hand rearing to replicate the care their mum should be giving them.
RSPCA inspector Charlotte Coggins, who is investigating for the animal welfare charity, said: '˜It's estimated the puppies are around 10 days old.
'˜They are tiny, they don't yet have their eyes open and need help feeding.
'˜Thankfully they are now getting the care they need and we hope they will all make a good recovery.'
The charity is now concerned for the welfare of the puppies' mother.
Inspector Coggins added: '˜We are very worried about the welfare of the mother dog as she will no doubt be really missing her pups, and could be suffering from mastitis after recently having so many puppies.
'˜I assume as they'd been left in the layby by the person responsible in the hope they would be found and helped.
'˜However, leaving such young puppies exposed like this without the mum they so desperately need risked their lives.
'˜Anyone with any information can call me in complete confidence on our inspectors' appeal line on 0300 123 8018.'