UPDATE: Major road re-opened following crash in Fareham
Emergency services were called to the scene at Newgate Lane following the incident at 9am.
Two people have been taken to hospital.
A spokesman from South Central Ambulance Service said the 42-year-old female car driver was taken to Queen Alexandra Hospital, in Cosham, with serious injuries. They are not thought to be life-threatening.
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Hide AdThe male lorry driver was also taken to QA Hospital after suffering minor injuries.
A spokeswoman for Hampshire Constabulary said officers closed the road so anyone injured could be treated.
Delays are still expected.
The air ambulance had been called but was stood down.