John Mousinho has been hit by injuries and suspensions going into the game, as his side look to maintain their sturdy start to the season.
But Chelsea new boy Tino Anjorin is in contention after joining on the eve of transfer deadine day.
Here’s how we think Pompey will line up as they go to Pride Park.
1. Pompey predicted line-up
Pompey boss John Mousinho has much to ponder in his team selection at Derby. Photo: Jason Brown
2. GK: Will Norris
A shining light this season and now nailed on as first-choice keeper. Photo: Jason Brown
3. Zak Swanson
Joe Rafferty is finishing his suspension - but Swanson now has the shirt. Photo: Jason Brown
4. RCB: Regan Poole
Becoming a big favourite after a flying start to his Fratton career. Photo: Jason Brown