The Blues head north to Gresty Road, after a powerful second-half showing in the 4-0 success against Doncaster Rovers last weekend.
Cowley named what he felt was the most attacking team of his Pompey reign against Gary McSheffrey’s men.
Now he has to decide whether to go with the same again, as they face another struggling team in the Railwaymen.
A start for Aiden O’Brien is also a big consideration after his goal off the bench at Fratton Park, while high-profile January arrival Tyler Walker has yet to score in five starts.
We’ve pulled together what we know to deliver what we feel will be Pompey’s line-up for the game.
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1. GK: Gavin Bazunu
About as nailed on a starter, fitness permitting, as is possible to be. Photo: The News
2. RCB: Hayden Carter
Really showing what he's about and growing in popularity with Pompey fans. Photo: The News
3. CB: Sean Raggett
Tough-as-nails nailed-on starter. Holds the defence together. Photo: The News
4. LCB: Connor Ogilvie
Could feel harshly done by to be dropped last weekend. May well return if Cowley feels his ability physically and aerially is more suited to keeping Crewe out. Photo: The News