So boss John Mousinho has decisions to make over how he covers those absences this weekend.
The Blues are boosted by the return of Kusini Yengi, however, after nearly eight weeks out with an ankle injury.
Here’s how we think Pompey will line up with some big calls to be made.
1. Pompey predicted line-up
Kusini Yengi is back in contention for Pompey against Port Vale. Photo: Jason Brown
2. GK Will Norris
Has there been a more consistent performer for Pompey this season? Probably not. Photo: Jason Brown
3. RB: Joe Rafferty
Okay, okay - Rafferty is also a very good shout when it comes to Pompey's most consistent performer... Photo: Jason Brown
4. CB: Sean Raggett
The chance is here. Been so unfortunate to be out of the side as Regan Poole flies and likely to be the first cab off the rank in terms of a replacement, as the Wales man serves a one-game ban. Photo: Jason Brown