A difficult challenge lies in wait against the Latics, after their relegation from the Championship.
John Mousinho welcomes some players back to the fold, as they aim to make it 21 league games unbeaten at the DW Stadium.
Here’s how we think the Blues will line up against Shaun Maloney’s side.
. Predicted Pompey line-up
Christian Saydee returns to the Pompey fold at Wigan. Photo: Jason Brown
. Goalkeeper: Will Norris
A key moment to preserve the win against Lincoln, with the stats saying Norris is continuing to perform beyond expectations. Photo: Jason Brown
. Right-back: Joe Rafferty
Has reached the levels he was at before suspension once again - and was a standout performer against Lincoln. Photo: Jason Brown
. Centre-back: Regan Poole
Will have to be careful as he walks a suspension tightrope - one more booking and it's a ban for the defender who's been oustanding. Photo: Jason Brown
. Centre-back: Conor Shaughnessy
Continues to fly under the radar - and continues to perform impressively when doing so. Photo: Jason Brown
. Left-back: Jack Sparkes
A performance of extremes against Lincoln. Gave away the ball for the goal and had some shaky moments - but also some impressive contributions and outstanding delivery. Photo: Jason Brown
. DCM- Marlon Pack
Has been a pillar of consistency this term and once again led by example. Photo: Jason Brown
1. Predicted Pompey line-up
Christian Saydee returns to the Pompey fold at Wigan. Photo: Jason Brown
2. Goalkeeper: Will Norris
A key moment to preserve the win against Lincoln, with the stats saying Norris is continuing to perform beyond expectations. Photo: Jason Brown
3. Right-back: Joe Rafferty
Has reached the levels he was at before suspension once again - and was a standout performer against Lincoln. Photo: Jason Brown
4. Centre-back: Regan Poole
Will have to be careful as he walks a suspension tightrope - one more booking and it's a ban for the defender who's been oustanding. Photo: Jason Brown