Here's all the key facts and figures you need to know ahead of the clash'¦
Pompey team news
Brett Pitman is fit to face the Iron.Â
The striker missed the Blues' Checkatrade Trophy clash against Tottenham under-21s with a knee injury last week.
Pitman is back in full training after recovering from his setback.
However, the former AFC Bournemouth marksman is likely to start on the bench, with Oli Hawkins set to continue leading Kenny Jacket's attack.Â
However, Joe Mason is set to miss the trip to Glanford Park with a groin injury.
The Wolves loanee is expected to be available for Walsall's visit to Fratton Park on Tuesday.Â
Dion Donohue (hamstring) has been earmarked to return to fitness at the start of December.Â
Likely Pompey line-up (4-2-3-1)
Craig MacGillivray; Nathan Thompson, Jack Whatmough, Matt Clarke, Lee Brown; Tom Naylor, Ben Thompson; Jamal Lowe, Gareth Evans, Ronan Curtis; Oli Hawkins. Substitutes: Luke McGee, Christian Burgess,Â Brandon Haunstrup, Ben Close, David Wheeler, Brett Pitman, Andre Green.
Scunthorpe team news
Scunthorpe are hoping to have George Thomas availableÂ for Pompey's visit.Â
The Welshman was included in Ryan Giggs' latest squad for their internationals against Denmark and Albania.
The Leicester loanee didn't feature in either of the Dragons' game but could start in a left-back role against the Blues.
Ryan Colclough is one who will definitely miss out.
The 23-year-old was forced off with what looked to be a serious knee injury in his side's win over Bristol Rovers last weekend.
Josh Morris was expected to return to full training this week after recovering from a fractured jaw,Â but won't be fit to face the League One leaders.
Likely Scunthorpe line-up (4-4-2)
Jak Alnwick; James Perch, Charlie Goode, Rory McArdle, Cameron Borthwick-Jackson; Andy Dales, Funso Ojo, Matthew Lund, George Thomas; Lee Novak, Ike Ogbo. Substitutes: Jonathan Flatt, Cameron Burgess, Lewis Butroid, Yasin Ben El-Mhanni, Clayton Lewis, Stephen Humphrys, Kyle Wootton.Â Â
Match odds (provided by the Betting Room, Southsea)
Bradford 16/5, draw 12/5, Pompey 1/1
Scunthorpe form guide
W Bristol Rovers, L Mansfield, W Burton, D Oxford, L Plymouth, L Blackpool
Pompey form guide
Â W Tottenham under-21s, W Maidenhead United, W Bradford, D Accrington, D Burton Albion, W Fleetwood
Top scorer: Jamal Lowe (7)
Most assists: Ronan Curtis (7)
Most games: Matt Clarke (22)
Form guide: W 15, D 5, L 2
Scunthorpe United stats
Top scorer: Lee Novak (7)
Most assists: Josh Morris (5)
Most games: Ryan Colclough (21)
Form guide: W 6, D 8, L 9
Friday (7.45pm): Coventry City v Peterborough United
Saturday (All 3pmÂ unless stated)
AFC Wimbledon v Southend UnitedÂ
Barnsley v Doncaster RoversÂ
Blackpool v Burton AlbionÂ
Bradford City v Oxford UnitedÂ
Charlton Athletic v Bristol RoversÂ
Gillingham v Luton TownÂ
Plymouth Argyle v Fleetwood TownÂ
Rochdale v Accrington StanleyÂ
Walsall v SunderlandÂ
Wycombe Wanderers v Shrewsbury Town