It is home to major names like Primark, Top Shop and many more.
However it has said goodbye to some big high street names over the years.
Here are some of the shops that used to call Commercial Road home and what they were replaced by.
Make sure to click through the full gallery!
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. Lost Commercial Road shops
GV of Commercial Road, Portsmouth on 19 March 2020. Picture: Habibur Rahman Photo: Habibur Rahman
. Sports Direct
Sports Direct closed its store in Commercial Road in October 2020 and moved into a new site in the Cascades Shopping Centre Photo: Google Maps
. Flannels
Flannels is opening a new store in Portsmouth in the site vacated by Sports Direct in 2020. It is 'coming soon'. Photo: JPIMedia
. Woolworths
The Woolworths store on Commercial Road was a hugely popular suggestion. The shop shut in 2009 as the company entered administration. Photo: Paul Jacobs
. Primark - replaced Woolworths
Woolworths former neighbour Primark has since expanded and taken over the former favourites space on Commercial Road to make one giant store. Photo: Sarah Standing
. Debenhams
Debenhams has closed in Commercial Road, Portsmouth, and plans have been submitted to demolish it. Picture: Chris Moorhouse (161220-26) Photo: Chris Moorhouse
. Burton/ Topman
The store which was home to Burton and Topman has shut down. The site remains empty in 2021. Picture: Habibur Rahman Photo: Habibur Rahman
. Allders
Allders finally lost its financial battle in 2012 when it fell into administration. It had done so seven years earlier, but was rescued by Tillman. Photo: Michael Scaddan
. Debenhams - replaced Allders
Debenhams replaced the Allders store in Commercial Road, Portsmouth. It has now closed itself. Photo: Malcolm Wells
21. JD Sports
JD Sports used to occupy a spot further down Commercial Road, however it shut in 2018 when the store moved to the former New Look site. Photo: Google Maps
22. Scotts - replaced old JD Sports store
Fashion retailer Scotts has moved into the site formerly occupied by JD Sports. Photo: JPIMedia
23. Game
Game had a store in Commercial Road until October 2020 - when the shop shut and moved into the Cascades Shopping Centre Photo: Google Maps
24. Empty site
The site of the former Game store in Commercial Road currently remains unoccupied as of November 2020. Photo: JPIMedia