The Blues have been brittle at the back in recent weeks and the partnership of Christian Burgess and Tom Davies is under scrutiny.
Davies remains the most likely to drop out should Pompey’s boss opt to make changes.
Elsewhere, Enda Stevens has been handed the all-clear following a hamstring injury scare against Notts County.
It ensures Cook has a fully-fit squad to chose from ahead of the trip to Cambridge United.
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Noel Hunt is challenging for a place on the bench.