During that time the Blues called upon many household names – Sol Campbell, Teddy Sheringham, David James, Peter Crouch, Steve Stone and Kanu, to name but a few.
Meanwhile, stars of the beautiful game also emerged such as Gary O’Neil, Matty Taylor, Lassan Diarra, Benjani and Glen Johnson.
But what about those who will be remembered in the history books but not necessarily in our memories from that golden era on the pitch?
In truth, there’s many – more than we'd probably realise.
So to help jog your memory, here’s 15 players who you probably forgot played for Pompey during those Premiership/Premier League days.
9. Dario Silva
The Uruguayan arrived at Fratton Park in 2005 with a decent reputation for both club and country. Goals were scored for the likes of Cagliari, Malaga and Sevilla, while he had amassed 40-plus appearances for Uruguay. Yet he was 31 when he joined Pompey and it appeared his best days were behind him. An ankle injury during his time on the south coast didn't help and he was restricted to just 15 appearances and three goals before having his contract cancelled in February 2006. Silva, tragically, had to have a leg amputated below the knee in September 2006 after the pick-up truck he was driving crashed in Montevideo. Photo: Steve Reid
10. Djimi Traore
The Champions League winner with Liverpool joined Pompey from Charlton for £1m in January 2007, despite having a reputation for being reckless. He made nine appearances over the second half of the 2007-08 season, but come the start of the following campaign he was well down the pecking order. A further five more outings were made before the defender joined Rennes on loan. He was shipped out to Birmingham in February 2009, before joining Monaco on a free transfer. Photo: JPIMedia
11. Lucien Aubey
The left-back joined Pompey on loan from French side Lens in January 2008. He would make just three appearances for Harry Redknapp's Blues before joining Rennes shortly after Pompey's FA Cup final win against Cardiff. He's in plenty of the pictures from that memorable day at Wembley as he joined in with the celebrations. Photo: Steve Reid
12. Angelos Basinas
The Greece midfielder, who won the European Championships with his country in 2004, was signed by Tony Adams in January 2009. He made his debut in the 3-2 Fratton Park defeat to Liverpool - but that game proved to be Adams' last in charge. And things quickly went down hill from that moment on, with Basinas featuring just six times under Paul Hart. He was given a chance to rectify his Fratton career following Hart's sacking under Avram Grant, featuring 15 times following his appointment in November 2009, but was released in August 2010. Photo: Denis Doyle