They come in for Ryan Tunnicliffe and Clark Robertson, who both drop to the bench for the Home Park encounter.
Hume’s return sees him given the left wing-back berth, with Connor Ogilvie taking Robertson’s place on the left of the back three.
'I don't think I realised how much it would mean': ex-Cardiff City and Bristol City man's Portsmouth admission as he chases winning Fratton feeling after homecoming
Former Portsmouth, Sunderland and Millwall ace Aiden O'Brien suffers setback as frustrating start to life at Shrewsbury continues
Danny Cowley makes Portsmouth team selection admission following Cheltenham win - and gives honest assessment of current squad amid early-season promotion hopes
The role ex-Leicester City, Birmingham City and Charlton Athletic man wants to maintain at Portsmouth after guiding city's young gems at Reading
How golden boot odds have shifted for Portsmouth, Ipswich Town, Plymouth Argyle, Bristol Rovers and Peterborough United front men after start to season
Meanwhile, Morrell partners Louis Thompson in the centre of midfield, replacing Tunnicliffe, who started at Ipswich.
However, there is no place in the 18-man squad for Michael Jacobs, who returned to training on Friday following injury.
Marcus Harness is also absent as he serves out the final match of a three-game ban following his Accrington red card.
Pompey: Bazunu, Carter, Raggett, Ogilvie, Romeo, Hume, Thompson, Morrell, Curtis, O’Brien, Hirst.
Subs: Webber, Tunnicliffe, Robertson, Jewitt-White, Mingi, Vincent, Walker.
A message from the Editor, Mark Waldron
You can support our local team of expert Pompey writers by subscribing here for all the latest news from Fratton Park for 9p a day, thanks to our 30%-off transfer window deal.