After four successive wins under Danny Cowley, the Blues have recently lost to Burton before drawing at Crewe Alexandra on Tuesday.
As a result, Pompey have dropped to sixth in the League One table and failure to win at Stadium MK could see them moved out of the play-off places.
The Blues’ lack of attacking options are well documented, with Ellis Harrison and Michael Jacobs out for the remainder of the season while Jordy Hiwula’s also absent.
It means Cowley’s unable to rotate any of the players in the front four positions.
However, will Pompey’s boss be tempted to make any further changes from the goalless stalemate at Gresty Road?
Scroll down and click through the pages to see how we think the Blues might line-up...
13. Sub 2 - James Bolton
Continues to be the model pro despite being out of favour. Photo: Graham Hunt
14. Sub 3 - Rasmus Nicolaisen
The Dane's prowess in possession is perhaps giving Danny Cowley something to think about. Photo: Nigel Keene
15. Sub 4 - Lee Brown
The vice-skipper's hamstring problem might not be as bad as first thought and he could return to the squad. Photo: Joe Pepler
16. Sub 5 - Andy Cannon
Must surely be pushing for a place back in the starting spot, although he was unused at Crewe. Photo: Joe Pepler