It represents only the 11th time the Blues have travelled to a Premier League club in the competition over the last 26 years, consisting of nine different teams.
So here are the previous 10 FA Cup trips to the home of top-flight clubs during that period, spanning from February 1997 to the present day...
5. Liverpool - February 2004
Jamie Carragher battles with Ivica Mornar drawing a 1-1 draw at Anfield in the FA Cup Fifth Round in February 2004. Picture: Laurence Griffiths/Getty Images Photo: Laurence Griffiths
6. Manchester United - January 2003
Svetoslav Todorov gets the ball past the United defence during an FA Cup Third Round match at Old Trafford in January 2003. Pompey lost 4-1. Picture: Laurence Griffiths/Getty Images Photo: Laurence Griffiths
7. Sunderland - December 1999
Michael Panopoulos was dismissed in the first half of Pompey's 1-0 defeat at Premier League Sunderland in the FA Cup Third Round in December 1999. Picture Allan Hutchings Photo: Allan Hutchings
8. Nottingham Forest - January 1999
Steve Claridge celebrates scoring Pompey's winner in the FA Cup Third Round match against Nottingham Forest at the City Ground in January 1999. Picture: Laurence Griffiths/Allsport Photo: Laurence Griffiths