It represents only the 11th time the Blues have travelled to a Premier League club in the competition over the last 26 years, consisting of nine different teams.
So here are the previous 10 FA Cup trips to the home of top-flight clubs during that period, spanning from February 1997 to the present day...
9. Aston Villa - January 1998
Dave Waterman tangles with Aston Villa's Savo Milosevic in an FA Cup Third Round replay at Villa Park as the Blues slip to a 1-0 defeat. Picture: Julian Herbert/Allsport Photo: Julian Herbert
10. Leeds - February 1997
Leeds' Gunner Halle is challenged by Paul Hall at Elland Road as Pompey claim a 3-2 win in the FA Cup Fifth Round in February 1997. Picture: Anton Want/Allsport Photo: Anton Want