John Mousinho faces some big decisions, particularly in attacking areas as Myles Peart-Harris returns to fitness and the likes of Kusini Yengi push for includsion.
Here's how we think he'll line up as he takes on former Southampton boss Nathan Jones at The Valley.
17. Sub 5: Gavin Whyte
Back in last week and toss-up between the Northern Ireland man and Josh Martin, if Myles Peart-Harris is back in the equation. Photo: Jason Brown
18. Sub 6: Christian Saydee
Not had too many minutes of late, but as he continues to show, a real impact player off bench. Photo: Jason Brown
19. Sub 7: Colby Bishop
Would raise a few eyebrows if the striker was rotated with Yengi and Bishop is still the main man, but may be horses for course up front over the coming weeks.