The Blues have an injury doubt in Marlon Pack heading into the game, with the club captain nursing an ankle injury from Saturday’s win against Wigan.
Connor Ogilvie, Anthony Scully, Kusini Yengi and Tom Lowery also remain out, leaving John Mousinho with a bit of a selection headache.
But with the Blues in impressive form this season and having plenty of options within the squad to chose from, there’s no need to panic.
Here’s how we believe the Blues will line up tonight, despite the absence of some key players.
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Pompey welcome Wycombe Wanderers to Fratton Park tonight Photo: Jason Brown
. Goalkeeper: Will Norris
No keeper has conceded fewer goals in League One this season. Is growing in confidence as the season gathers pace. Photo: Jason Brown
. Right-back: Joe Rafferty
All Pompey fans know the right-back berth is in very capable hands thanks to the former Preston man. And with Zak Swanson breathing heavily down the Scouser's neck, Rafferty knows he needs to maintain those high performance levels. It's a win-win for Pompey! Photo: Jason Brown
. Centre-back 1: Regan Poole
Not only is the former Lincoln man a tower of strength at the back, he's also a major threat going forward as three goals in four games proves. Have said it before, but it's worth saying again: 'what a player Pompey signed in the summer!' Photo: Jason Brown
. Centre-back 2: Conor Shaughnessy
Bearing in mind Shaughnessy arrived in the summer to act as back-up to Poole, Sean Raggett and Ryley Towler, it's testament to him that he hasn't looked back after being handed his league debut at Stevenage. Has been an ever-present since that golden opportunity and is forming a good understanding with Poole Photo: Jason Brown
. Left-back: Jack Sparkes
Is proving a good deputy for the injured Connor Ogilive, after demonstrating some initial nerves. Wil continue to deputise as Pompey wait for Ogilvie to return. Photo: Jason Brown
. Central midfield 1: Joe Morrell
The Welshman will have a key part to play if Marlon Pack is forced to sit the Wycombe game out through injury. He's always in the thick of it at the best of times. That will again be crucial tonight - as will the need to keep a calm head. His experience will be key. Photo: Jason Brown
1. psi_jb_wigan_athletic_portsmouth_300923_111.JPG
Pompey welcome Wycombe Wanderers to Fratton Park tonight Photo: Jason Brown
2. Goalkeeper: Will Norris
No keeper has conceded fewer goals in League One this season. Is growing in confidence as the season gathers pace. Photo: Jason Brown
3. Right-back: Joe Rafferty
All Pompey fans know the right-back berth is in very capable hands thanks to the former Preston man. And with Zak Swanson breathing heavily down the Scouser's neck, Rafferty knows he needs to maintain those high performance levels. It's a win-win for Pompey! Photo: Jason Brown
4. Centre-back 1: Regan Poole
Not only is the former Lincoln man a tower of strength at the back, he's also a major threat going forward as three goals in four games proves. Have said it before, but it's worth saying again: 'what a player Pompey signed in the summer!' Photo: Jason Brown