Eighteen members of head coach John Mousinho’s new-look squad have already featured for the Blues in League One this term.
However, chances are the Blues will make minimal changes to the side that beat Leyton Orient 4-0 on Saturday – leaving the likes of Fratton favourite Ryley Towler unable to force his way back into the side.
Meanwhile, the game is likely to have come too soon for Paddy Lane, who have recovered from a foot injury.
Here’s how we think Pompey could line up against the Grecians.
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Pompey are back in action against Exeter on Tuesday night Photo: Jason Brown
2. Goalkeeper: Will Norris
The former Burnley and Peterborough keeper looks a solid addition and appears to fit perfectly into John Mousinho's style of play. Will be delighted to have recorded his first clean sheet for the Blues against Leyton Orient and is expected to line up against the Grecians. Photo: Jason Brown
3. Right-back: Joe Rafferty
The Scouser produced a man-of-the-match display against Leyton Orient, which was the perfect response to Zak Swanson's impressive showing at Forest Green. Pompey are in good hands when it comes to the right-back berth - and at the minute, Rafferty is in full control, which is bad news for Swanson. Photo: Jason Brown
4. Centre-back 1: Regan Poole
We were all told that Poole's summer arrival was a real coup for Pompey. We're now all seeing that for ourselves! Photo: Jason Brown