But how does John Mousinho approach the game, as he goes in search of a massive three points in the bid to stay in the second tier?
Mousinho has indicated there will be changes for the meeting with John Eustace’s side - and this is how Pompey writer Jordan Cross thinks he will go.
1. Pompey predicted line-up
Here's how we think Pompey will line up against Derby. | Getty Images
2. GK Nicolas Schmid
More credit in the bank on Wednesday - Austrian has to be in player of the season contention. Photo: Jason Brown
3. RB Jordan Williams
Gathering impetus after injury return and could well end up sharing duties with Terry Devlin on third game in eight days. Photo: Jason Brown
4. CB Regan Poole
Back to the old Regan Poole on Wednesday night - and don't Pompey need more of the same now. Photo: Jason Brown
1 / 6