The international break, coupled with Saturday’s trip to Blackburn, means the Blues’ last game was the 3-1 win against Preston North End on November 9.
The extended period without a game, will have given John Mousinho a chance to get some of his walking wounded back.
But what’s the current injury situation ahead of the PO4 showdown for both clubs?
Here’s the latest.
1. Fratton Park pitch general view.jpg
Pompey take on Millwall tonight in the Championship. Photo: National World
2. Conor Shaughnessy - Out
The Pompey defender is out until the new year with a fresh calf issue separate to the one that hasn't seen him play since the visit of Luton back in August. Photo: National World
3. Jacob Farrell - Out
A MCL injury has dogged the 22-year-old’s early days on the south coast, with a start in September against Sheffield United his sole appearance to date. Is on the mend, but yet to return to full training. Photo: Jason Brown
4. Jordan Williams - Out
The extra days between games won't make any difference to the full-back's chances of playing. He remains out with a hamstring injury. Photo: Jason Brown